Key Takeaways
- ZO Skin Health Growth Factor Serum contains plant-derived ingredients such as Buddleja Davidii Meristem Cell Culture and fermented ginseng, which may have growth factor–like properties, but it does not include recombinant human growth factors like sh-Oligopeptide-1 (EGF).
- The serum’s main peptide active is Dipeptide Diaminobutyroyl Benzylamide Diacetate, a neuropeptide that may help reduce the appearance of expression lines.
- Easydew DW-EGF Collagen Silkream Ampoule is the top result in SKINSKOOL's compare results and includes that same neuropeptide, plus sh-Oligopeptide-1 (EGF), a lab-engineered growth factor modeled after human protein structure.
- Easydew EX also contains Palmitoyl Tripeptide-5 and barrier-supportive ingredients like Beta-Glucan and Ceramide NP, suggesting broader regenerative potential.
- Based on ingredient comparison, Easydew EX is a strong functional dupe that may more closely align with what users expect from a product marketed as a “growth factor serum.
What is ZO Skin Health Growth Factor Serum?
ZO Skin Health Growth Factor Serum is a lightweight anti-aging gel marketed to improve the appearance of wrinkles and skin firmness. While it’s positioned as a “growth factor” serum, the ingredient list does not include the type of lab-synthesized, human protein–based growth factors commonly associated with epidermal regeneration, such as sh-Oligopeptide-1 (EGF).
Instead, the formula appears to rely on plant-derived and botanical components that may have growth factor–like effects. One notable ingredient is Buddleja Davidii Meristem Cell Culture, a plant stem cell extract often promoted for antioxidant protection and skin renewal. Additionally, it includes Lactobacillus/Panax Ginseng Root Ferment Filtrate, which is sometimes positioned as a bio-ferment with regenerative properties. These ingredients may support the skin’s appearance but are not the same as recombinant human growth factors.
The primary peptide active is Dipeptide Diaminobutyroyl Benzylamide Diacetate, a neuropeptide that mimics the muscle-relaxing effect of snake venom and may help smooth dynamic wrinkles. Other components like ATP, phospholipids, and botanical extracts offer hydration and barrier support.
Does it actually contain a growth factor?
It depends on how "growth factor" is defined. ZO’s formula does include plant stem cell extracts and fermented botanicals that are sometimes described in marketing as growth factor–like. However, it does not include lab-engineered growth factors modeled on human proteins, such as sh-Oligopeptide-1 (EGF), which is often what users expect when they see “growth factor” on a label.
So while it may contain botanical actives that support skin renewal, it lacks the synthetic recombinant peptides that signal epidermal regeneration at the cellular level.
What is DW-EGF, and is it in Easydew?
Yes. Easydew EX DW-EGF Collagen Silkream Ampoule contains DW-EGF, which is a proprietary form of sh-Oligopeptide-1 (Epidermal Growth Factor). This is a recombinant human peptide that may help stimulate skin cell regeneration and repair. It’s a widely used and accepted growth factor in cosmetic formulations.
Does Easydew contain the same peptide as the ZO serum?
Yes. Both products include Dipeptide Diaminobutyroyl Benzylamide Diacetate, which is commonly known by its trade name Syn-Ake. This peptide is used for its wrinkle-relaxing properties and may help improve the appearance of fine lines. So at minimum, the Easydew formula contains the same neuropeptide active as ZO’s product.
What other anti-aging peptides are in Easydew EX?
Easydew EX appears to go further by including:
- sh-Oligopeptide-1 (EGF), a true epidermal growth factor
- Palmitoyl Tripeptide-5, a signal peptide that may support collagen synthesis
- Beta-Glucan, Ceramide NP, Panthenol, and Soluble Collagen, which support hydration and skin barrier repair
This gives it a broader range of functionally active ingredients targeting regeneration, moisture retention, and firmness.
Is Easydew a true dupe for ZO Skin Health Growth Factor Serum?
Functionally, yes. It replicates the main neuropeptide found in the ZO serum and includes additional growth factor and collagen-supporting peptides that the original product does not. While the formulas are not identical, Easydew could be considered a strong dupe based on shared peptide strategy and overlapping skin benefits.
What’s the price difference?
- ZO Skin Health Growth Factor Serum: Approximately $195
- Easydew EX DW-EGF Collagen Silkream Ampoule: Around $55
This significant price difference makes Easydew a compelling option for those seeking to try out similar peptide benefits at a more accessible cost.
Final Thoughts
For users focused on wrinkle reduction and regenerative support, Easydew seems to offer not only a comparable alternative but potentially a more peptide-rich formulation. It includes both the neuropeptide found in ZO’s product and a true EGF, which ZO’s formula lacks. While ingredient concentration and formulation nuances will affect performance, the overlap in actives, combined with the lower price point, make it a dupe worth considering.
